A new technology to counter iron deficiency

Sucrosomial® iron is an progressive oral iron expertise, during which ferric pyrophosphate (trivalent iron) is transported inside a matrix of phospholipids and sucrose esters of fatty acids. This construction, known as Sucrosome®, permits excessive absorption of iron and optimum gastrointestinal tolerability.

Iron deficiency (ID)

Iron is an important component for the physique. It promotes the formation of hemoglobin and myoglobin, helps the immune system and regular cognitive operate in addition to supporting progress in kids and adolescents.

The causes that may result in the rise within the want for iron are completely different, however, in all circumstances, it’s mandatory to revive the physique’s stability of this nutrient so as to facilitate sure regular physiological capabilities of our our bodies.

Iron deficiency (ID) is a situation characterised by a low degree of this mineral within the physique, that, if not recovered, results in an anemic scientific situation. Iron deficiency anemia (IDA) happens when the physique will not be in a position to fulfill a proper hemoglobin manufacturing, which is pivotal to make sure the oxygenation of tissues and cells of the physique.

The principle causes of ID are elevated demand, lowered absorption, and elevated lack of iron.

Within the image under is proven the presence of ID on particular scientific situations:

Supply: Susana Gómez-Ramírez et al., Sucrosomial® Iron: A New Technology Iron for Bettering Oral Supplementation.

World Health Organization (WHO) has defined the values of hemoglobin (Hb) as normal range at 13-18 g/dL for men and 12-16 g/dL for women; below these values, iron deficiency anemia is diagnosed. Other important markers to be considered for ID anemia are: ferritin, a storage protein able to contain up to 4500 iron atoms, transferrin saturation (%TSAT), as this glycoprotein is able to transport iron to the tissues and body districts that use this mineral, and sideremia, which indicates the amount of iron bound to transferrin in the bloodstream.

Iron Deficiency itself, instead, doesn’t always show hematological alterations; in fact, the hemoglobin level can be within the normal range, but the ferritin and the saturation of transferrin can be below. If the deficiency is not timely adjusted, it could develop in IDA.

The common symptoms related with ID and IDA, are:

• Paleness;
• Weak point;
• Dizziness;
• Irritability;
• Problem concentrating.

Commonly, ID is treated with oral iron salts (e.g. iron sulfate); however, conventional oral iron supplements are poorly absorbed by the body and lead to gastrointestinal side effects, with consequently reduced compliance and frequent drop outs by the patients.

Sucrosomial® Iron (Sideral ®)

This new patented technology represents an innovative oral iron-containing carrier, in which ferric pyrophosphate is transported within a phospholipid plus sucrester matrix.

The result is a high gastrointestinal tolerability and easier iron absorption at the intestinal level. In the recent years many scientific evidences (each preclinical and scientific trials) have been printed on Worldwide Journals confirming Sucrosomial® expertise effectiveness.

Gastro-resistance and Absorption

The gastro-resistance is due primarily to the sucrester matrix, as demonstrated by in vitro research, that protects the iron from the acid gastric fluid.

This enables the Sucrosome® to completely attain the intestinal mucosa, the place it’s absorbed by enterocytes by way of 2 routes: para-cellular and trans-cellular.

Moreover, within the intestinal tract, additionally the Membranous cells (M cells) of the Peyer’s patches are concerned for Sucrosomial® iron absorption. Research have demonstrated, in actual fact, that these cells are ready to participate to the absorption of the Sucrosome® and to switch it to the lymphatic system.

Distribution

Scientific evidences on Sucrosomial® iron demonstrate that this newer technology allows the absorption of iron by the intestinal tract and its distribution to the target tissues.

Considering its structure, similar to chylomicrons (gut lypoproteins able to transport lipophilic substances), it can be assumed that Sucrosomial® iron reaches the liver, where the epatocytes are able to metabolize the phospholipid matrix, thanks to lysosomial enzymes, and to make available the ferric pyrophosphate for transferrin bound, and consequent tissues distribution, in particular to the bone marrow to form new red blood cells.

Iron Deficiency in Clinical Practice

Several studies in scientific literature confirm the efficacy of Sucrosomial® iron supplementation in lots of scientific settings, the place the deficiency of iron is frequent, for instance: ginecology, oncology, nephrology, cardiology and particularly in gastroenterology.

In gastroenterology, ID and IDA are probably the most frequent systemic issues in Inflammatory Bowel Illness (IBD), celiac illness and weight problems. All these pathologies result in continual irritation, that limits absorption and use of iron by the physique. In sufferers with practical ID, the supplementation of standard oral iron normally isn’t in a position to resolve this drawback, as a result of proinflammatory cytokines are produced by the organism after irritation. These cytokines stimulate the manufacturing and improve of hepcidin ranges, a peptide hormone produced by the liver, which works by lowering serum iron focus. Many research in gastroenterology show that the supplementation with Sucrosomial® iron permits to revive regular hematological ranges, and consequently to grant the traditional operate of purple blood cells and hemoglobin.

Conclusion

The innovation of Sucrosomial® technology is characterized by an excellent tolerability and it allows the iron intake anytime in the day (with meal or far from meals), for long periods of time, and prevents any discomfort commonly associated with iron intake, such as metallic and unpleasant aftertaste, irritation of the gastric mucosa, nausea or constipation. Overcoming the limits related to the conventional supplementation of iron, Sucrosomial® iron promotes the intake of this important nutrient in all situations of deficiency or increased needs for iron.

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